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(8)
By Target- RIP kinase
- Autophagy(1)
- Ferroptosis(1)
- Indoleamine 2,3-Dioxygenase (IDO)(1)
- Necroptosis(1)
- Others(1)
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Results for "
rip1 kinase inhibitor 1
" in TargetMol Product Catalog- Inhibitors & Agonists10
RIP1 kinase inhibitor 1
T127252095515-38-9
RIP1 kinase inhibitor 1 is an orally available and brain-penetrating inhibitor of RIP1 kinase with pKi of 9.04.
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Necrostatin-1
Necrostatin 1, Nec-1
T18474311-88-0
Necrostatin-1 (Nec-1) is a specific RIP1 inhibitor and necrotic apoptosis inhibitor, which inhibits TNF-α-induced necrotic apoptosis and also inhibits IDO.
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RIPK1-IN-4 
T127301481641-08-0In house
RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase).
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GSK963
GSK963 (Racemate)
T50542049868-46-2
GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).
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GSK2982772
T71511622848-92-3
GSK2982772 is an inhibitor of receptor interacting serine threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
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RIP1 kinase inhibitor 4
T790412919836-00-1
RIP1 Kinase Inhibitor 4 (Compound 3) is an effective inhibitor of RIP1K, exhibiting an EC50 of ≤ 1000 nM [1].
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RIP1 kinase inhibitor 5
T790422428422-17-5
RIP1 kinase inhibitor 5 (example 1) is a potent regulator of tumor immunity, inhibiting RIP1 and similarly to SIR1-365 (compound 13), suppresses necrosis and ferroptosis [2].
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RIP1 kinase inhibitor 6
T790432428401-62-9
RIP1 Kinase Inhibitor 6 is a potent and selective inhibitor of RIP1 kinase, demonstrating inhibitory activity with an IC50 of less than 100 nM in a human R1P1 kinase assay[1].
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RIP1 kinase inhibitor 7
T790442428401-23-2
RIP1 Kinase Inhibitor 7 (Compound 41) serves as a potent inhibitory agent for receptor interacting protein 1 kinase (RIP1) with an IC50 of under 100 nM. Additionally, it demonstrates an EC50 ranging from 1 to 100 nM in cell necrosis assays [1].
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RIP1 kinase inhibitor 8
T796052226735-54-0
RIP1 Kinase Inhibitor 8 (Compound 77), a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor, exhibits an IC50 of 20 nM and effectively prevents necrotic cell death. It also demonstrates a favorable pharmacokinetic profile across multiple species [1].
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