riboswitch

Roseoflavin, a chemical analog of FMN and riboflavin that has antimicrobial activity, can directly bind to FMN riboswitch aptamers and downregulate the expression of an FMN riboswitch-lacZ reporter gene in B. subtilis.

Ribocil-C is a selective inhibitor of the bacterial riboflavin riboswitch, acting as a synthetic analogue of flavin mononucleotide (FMN). It suppresses ribB gene expression and inhibits bacterial cell growth.

Ribocil-C Racemate is the racemate of Ribocil-C, a highly selective inhibitor of bacterial riboflavin riboswitches that control the expression of de novo riboflavin (RF, vitamin B2) biosynthesis in Escherichia coli.

Riboswit-modulator-1 (Compound A1) is a covalent RNA ligand that acts as a regulator of the bacterial flavin mononucleotide riboswitch (FMN riboswitch). It modifies unpaired guanine residues (G11 and G62) near the FMN binding site through a proximity-driven mechanism, disrupting its conformational change. Riboswit-modulator-1 functions as a negative antagonist by eliciting effects opposite to those of the natural effector molecule.

Riboflavin 5'-monophosphate (FMN) is a coenzyme that is tightly bound to enzymes catalyzing oxidation and reduction reactions in a variety of biosynthetic pathways. FMN also binds the FMN riboswitch (RFN element) on RNA to alter gene regulation. FMN is a substrate of FMN phosphohydrolases and is used to study their function.

5'-pGpG is a linearized form of cyclic di-GMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).1,2,3It is a metabolite of cyclic di-GMP formedviahydrolysis by various phosphodiesterases (PDEs) that binds to the cyclic di-GMP-I riboswitch with reduced affinity compared to cyclic di-GMP.4,55'-pGpG is intended for use as a negative control for cyclic di-GMP signaling.

Z1913661252 is a novel riboswitch activator, binding ZTP riboswitches, and activating transcription more strongly than ZMP in vitro.

Preq1-Dihydrochloride (pre-queuosine1 Dihydrochloride) is an intermediate of the queuosine pathway, it binds with high affinity to the aptamer of PreQ1 riboswitch, which attenuates protein expression.