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Results for "
protackrasdegrader4
" in TargetMol Product Catalog- Inhibitors & Agonists1
- PROTAC Products1
PROTAC K-Ras Degrader-4
T2060452938169-99-2
PROTAC K-Ras Degrader-4 (Compound 4) is a proteolysis-targeting chimera (PROTAC) molecule designed to selectively degrade oncogenic mutants of K-Ras, effectively degrading KRASG12D in the GP5d cell line and KRASG12V in SW620 cells with DC50 of 1 nM and 13 nM, respectively; it concomitantly inhibits the downstream MAPK signaling pathway and represents a novel therapeutic strategy for cancer research targeting previously undruggable Ras mutations.
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