prolyl endopeptidase inhibitor 1

Prolyl Endopeptidase Inhibitor 1 is a potent inhibitor of prolyl endopeptidase (PEP; PE)(Ki : 15 nM) , has anti-amnesic effect.

S 17092 (S 17092-1) is a highly potent, reversible, and orally active small-molecule inhibitor of brain peptidylprolyl endopeptidase (PEP), with a binding constant (Ki) of 1.5 nM and an IC₅₀ of 1.2 nM against recombinant human PEP. By slowing the degradation of various neuroactive peptides, including Substance P, thyrotropin-releasing hormone (TRH), and arginine vasopressin (AVP), S 17092 increases the levels of these peptides in the brain and improves age-related or drug-induced memory and cognitive impairments in various rodent and primate animal models. S 17092 has been used in studies related to Alzheimer’s disease and cognitive impairment to evaluate the role of PEP regulation in neural function.

Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific and orally active inhibitor of prolyl endopeptidase (PREP) with an IC50 of 0.4 nM against porcine PREP [1] [2] [3].

Z-Thioprolyl-Thioproline is a prolyl endopeptidase inhibitor derived from bovine brain, exhibiting inhibition constants of IC50 = 16 µM and Ki = 37 µM. This compound is utilized in the investigation of neurological disorders, including memory and cognitive disorders [1].

Z-Thioprolyl-Thiazolidine is a potent, specific inhibitor of bovine brain prolyl endopeptidase, demonstrating an inhibition constant (K i value) of 0.36 nM [1].

Z-Pro-Pro-aldehyde-dimethyl acetal is a potent prolyl endopeptidase (PREP) inhibitor, effectively impeding the activity of this cytoplasmic serine endoprotease with an IC50 of 12 nM. Its significance lies in its role in modulating cognitive dysfunction associated with aging and neurodegenerative conditions, such as Alzheimer's disease [1] [2].

Prolyl Endopeptidase Inhibitor 2 (Compound 8), a proline endopeptidase (PEP) inhibitor, exhibits an IC50 value of 31.11 μM. This compound is applicable in research related to neurodegenerative diseases [1].

BR102910 (4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-) is a selective inhibitor of fibroblast activated protein (FAP).