prodigiosin

Prodigiosin is a natural red pigment and secondary metabolite that inhibits the Wnt/β-catenin pathway and exhibits antibacterial, antifungal, antimalarial, anticancer, and immunosuppressive activities.

Prodigiosin hydrochloride, a red pigment, is a bioactive secondary metabolite produced by bacteria. It exhibits potent proapoptotic activity and functions as an inhibitor of the Wnt/β-catenin pathway. Additionally, this compound possesses antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties.

Undecylprodigiosin hydrochloride, a member of the prodigiosin family, functions as an effective antibiotic. It selectively induces apoptosis in human breast cancer cells independent of p53. Additionally, this compound exhibits immunosuppressive, anticancer, and antibacterial activities.

Undecylprodigiosin is a classical cytotoxic immunosuppressant, suppressing immune functions. It also inhibits DNA synthesis.

16-Hydroxycleroda-3,13-dien-15,16-olide and prodigiosin are candidates for autophagy inducers that can trigger cell death as a supplement or alternative medicine for cancer therapy. 16-Hydroxycleroda-3,13-dien-15,16-olide regulates the expression of histone-modifying enzymes (PRC2 complex) and induces apoptosis in CML [K562] cells; it also exhibits anti-inflammatory activity, showing promising NO inhibitory activity at 10 ug/mL.