pm-150

Vedaprofen (PM 150) inhibits COX-1 and reduces prostaglandin H2 synthesis with anti-inflammatory activities. Vedaprofen is an inhibitor of Escherichia coli sliding clamp with the IC50 of 222 μM and Ki of 131 μM.

Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM).

Chroman 1 dihydrochloride is a selective and potent inhibitor of ROCK, acting more strongly on ROCK2 (IC50: 1 pM) than ROCK1 (IC50: 52 pM) and also inhibiting MRCK activity (IC50: 150 nM).

MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.

ESBA-105 represents a highly stable, humanized single-chain Fv (scFv) antibody fragment specifically engineered to target and neutralize human tumor necrosis factor-alpha (TNF-α) with exceptional binding affinity. It effectively facilitates the measurable blockade of TNF-mediated pro-inflammatory signaling and apoptosis across various preclinical experimental models to evaluate the optimization of tissue penetration and pharmacokinetic stability during strictly monitored laboratory observation periods and functional neutralization assays.

Gartisertib-d8 (VX-803-d8) is the deuterated form of Gartisertib. Gartisertib (VX-803) acts as an orally active, selective ATP-competitive ATR inhibitor, with a Ki of less than 150 pM. It effectively inhibits ATR-driven phosphorylation of checkpoint kinase-1 (Chk1), with an IC50 value of 8 nM, and exhibits antitumor activity.