pleuromutilin

Pleuromutilin (Drosophilin B) is an inhibitor of bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria.

Dihydropleuromutilin, a semisynthetic antibiotic derived from pleuromutilin, exhibits antimicrobial efficacy against S. aureus, M. hominis, M. gallisepticum, and M. hyorhinis, with minimum inhibitory concentrations (MICs) of 0.5, 0.3, 0.3, and 2 µg/ml, respectively.

Retapamulin (SB-275833), a Pleuromutilin Antibacterial, binds to both E. coli and S. aureus ribosomes with similar potencies (Kd: 3 nM).

Tiamulin (Thiamutilin) is a semisynthetic pleuromutilin antibiotic

Lefamulin acetate (BC-3781 acetate) (formally BC-3781 acetate) is a novel pleuromutilin antibiotic and is the first to be used for the systemic treatment of bacterial infections in humans. Lefamulin acetate (BC-3781 acetate) inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, preventing the binding of transfer RNA for peptide transfer. Lefamulin acetate (BC-3781 acetate) is an orally active antibiotic for community-acquired bacterial pneumonia (CABP) treatment.

Antibacterialagent 267 (Compound h19) is a derivative of pleuromutilin with potent antibacterial activity against Gram-positive bacteria. It demonstrates efficacy in a mouse model infected with methicillin-resistant Staphylococcus aureus (MRSA).

Antibacterialagent 301 (compound 14c) is a pyridinecarboxamide derivative of pleuromutilin, exhibiting broad-spectrum antibacterial activity as well as significant antimycoplasmal effects. It inhibits the peptidyl transferase center (PTC), disrupts biofilms, and damages the cell membranes of multi-drug resistant (MDR) bacteria. In a murine model of systemic methicillin-resistant Staphylococcus aureus (MRSA) infection, Antibacterialagent 301 demonstrated efficacy. It can be used in research on multi-drug resistant bacterial infections.

Antibacterial agent 90 (6n) is a pleuromutilin derivative with antibacterial activity against Gram-positive pathogens (GPPs) and Mycoplasma pneumoniae.

Valnemulin, a broad-spectrum pleuromutilin antibiotic, targets peptidyl transferase within the 50S ribosomal subunit, effectively used in veterinary medicine to address swine diseases such as B. hyodysenteriae and M. hyopneumoniae.

Tiamulin (Standard) is the standard substance of Tiamulin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Tiamulin (Thiamutilin) is a semisynthetic pleuromutilin antibiotic