phenotype — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9020	GSK620		Epigenetic Reader Domain
	GSK620 is a pan-BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.GSK620 is highly selective for the BET-BD...		Epigenetic Reader Domain
T3144	BML-284	Wnt agonist 1	Wnt/beta-catenin
	BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.		Wnt/beta-catenin
T3206	NKL 22	Histone Deacetylase Inhibitor IV,PAOA	HDAC
	NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.		HDAC
T2895	Lupeol	Fagarasterol,Monogynol B,Clerodol,(3β,13ξ)-Lup-20(29)-en-3-ol,Farganasterol	Apoptosis , Androgen Receptor , Akt
	Lupeol (Monogynol B) is a novel androgen receptor inhibitor with anti-inflammatory and antioxidant activity.		Apoptosis , Androgen Receptor , Akt
T8820	BML-284 hydrochloride	BML-284 HCL,Wnt agonist 1 HCL	Wnt/beta-catenin
	BML-284 hydrochloride (Wnt agonist 1 HCL) is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.		Wnt/beta-catenin
T22276	Bis(maltolato)oxovanadium(IV)	BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV)	Phosphatase , Others
	Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases)inhibitor with insulin-mimicking effects and anti-diabetic properties. BMOV is a potent i...		Phosphatase , Others
T15168	DRF-1042		Others
	DRF-1042 acts to inhibit DNA topoisomerase I. DRF-1042 displays perfect anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype.		Others
T5170	KHS101 hydrochloride		FGFR , Microtubule Associated
	KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.		FGFR , Microtubule Associated
T4831	α,α-Dimethylglycine	2-Aminoisobutyric acid,α-Aminoisobutanoic acid	Others , Endogenous Metabolite
	NSC-16590 (2-Aminoisobutyric acid) is a nonprotein amino acid (is an end product of pyrimidine Metabolism) excreted in the urine of about 5% of healthy individuals, and high excretion is an autosomal recessive phenotype.		Others , Endogenous Metabolite
T77379	Bexmarilimab	FP-1305	Others
	Bexmarilimab (FP-1305) is a highly potent humanized anti-CLEVER-1 IgG4 antibody with an IC50 value of 4.51 nM. Bexmarilimab promotes immune conversion of tumor-associated macrophage phenotype M2 to M1. Bexmarilimab can b...		Others
T9682	AZD-4877	AZD4877	Apoptosis , Kinesin
	AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and med...		Apoptosis , Kinesin
T63049	CHD1Li 6.11		Others
	CHD1Li 6.11 is a potent inhibitor of oncogenic CHD1L, acting on the cat-CHD1L recombinant protein (IC50: 3.3 μM). CHD1Li 6.11 is an orally active antitumour agent that significantly reduces the tumour volume of CRC xenog...		Others
T11134	DZ2002		Others
	DZ2002, an orally active, reversible, and low-cytotoxic type III SAHH inhibitor (Ki=17.9 nM), exhibits significant immunosuppressive activity. It effectively prevents experimental dermal fibrosis by reversing the profibr...		Others
T27537	Hexafluoro
	Hexafluoro is an inhibitor of DRP1 phosphorylation. Honokiol DCA stimulates a phenotype suggestive of respiration through mitochondrial normalization and demonstrates activity in Vemurafenib-resistant melanoma in vivo.
T27551	Honokiol DCA	Honokiol Bis-Dichloroacetate
	Honokiol DCA is an inhibitor of DRP1 phosphorylation. Honokiol DCA stimulates a phenotype suggestive of respiration through mitochondrial normalization and demonstrating activity in Vemurafenib-resistant melanoma in vivo...
T70367	SNU-BP
	SNU-BP is an agonist of PPAR-gamma, inhibiting lipopolysaccharide (LPS)-induced NO production and pro-inflammatory cytokines. SNU-BP potentiates interleukin-4-induced arginase-1 expression, and promotes microglial polari...
T21317	Avanbulin	BAL27862,BAL-27862,BAL 27862
	Avanbulin is a potent inhibitor of tubulin polymerization with antitumor activity. It elicits a unique microtubule (MT) phenotype, distinct from colchicine, paclitaxel, and vinblastine has broad in vitro anti-proliferati...
T69782	GS-9822
	GS-9822 is a novel LEDGIN, an inhibitor that targets the binding pocket of LEDGF/p75 which is a cellular cofactor that substantially contributes to HIV integration site selection, displaying a block-and-lock phenotype in...
T72430	L-Kynurenine sulfate
	L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist, activates AHR-driven polarization of naive T cells towards the anti-inflammatory Treg phenotype.
T40099	ALV2
	ALV2 is a potent and selective Helios degrader compound that binds to the CRBN protein, exhibiting an IC50 value of 0.57 μM. Helios, a zinc-finger transcription factor, plays a crucial role in preserving a stable T reg c...