pdk-3

VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism and induces context-dependent cytosta

PS10 is a broad-spectrum PDK inhibitor that inhibits PDK2, PDK4, PDK1, and PDK3. It significantly increases pyruvate dehydrogenase complex activity, and is used in research on obesity and type 2 diabetes.

JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.

PDK4-IN-1 hydrochloride, an anthraquinone derivative, is a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with an IC50 value of 84 nM.

PDK-IN-3 (compound 1) is a potent pan-inhibitor of PDK, with IC50 values of 109.3 nM, 135.8 nM, 458.7 nM, and 8.67 μM for PDK 1-4, respectively. Additionally, PDK-IN-3 induces proliferation and apoptosis in A549 cells.

OSU-02067 is a selective inhibitor of 3-phosphoinositide-dependent protein kinase-1 (PDK-1) with an IC50 value of 9 μM. It shows potential for research in solid tumors, including prostate cancer, breast cancer, and colon cancer.