pc3m

Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2.

Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation. Stattic has antitumor activity and induces apoptosis.

KGP94 is an inhibitor of cysteine protease Cathepsin L(CTSL).

Bacopaside X (Standard) is a reference standard for research and analysis in studies involving Bacopaside X. Bacopaside X is a triterpenoid saponin isolated from Bacopa monniera that exhibits strong antifungal and anticancer activities by actively suppressing pathogenic fungal growth and tumor progression, demonstrated through inhibition of Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus at MIC values of 50 µg/ml, along with significantly decreasing proliferation in cancer cell lines MDA-MB-231, SHG44, HCT8, A549, and PC3M with IC50 values of 14.3, 15.9, 9.8, 9.7, and 10.1 µM respectively. Bacopaside X additionally reduces tumor growth by 84.13% in an S180 sarcoma mouse allograft model when administered at a dose of 50 µmol/kg, indicating substantial therapeutic potential.

Bacopaside X is a triterpenoid saponin isolated from Bacopa monniera that exhibits strong antifungal and anticancer activities by actively suppressing pathogenic fungal growth and tumor progression, demonstrated through inhibition of Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus at MIC values of 50 µg/ml, along with significantly decreasing proliferation in cancer cell lines MDA-MB-231, SHG44, HCT8, A549, and PC3M with IC50 values of 14.3, 15.9, 9.8, 9.7, and 10.1 µM respectively. Bacopaside X additionally reduces tumor growth by 84.13% in an S180 sarcoma mouse allograft model when administered at a dose of 50 µmol/kg, indicating substantial therapeutic potential.