patu

PATU is a viricide.

Patulin (Claviform) is a mycotoxin produced by a variety of molds commonly found in rotting apples, including Aspergillus and Penicillium.

Mapatumumab (HGS-ETR1) is a fully human agonistic monoclonal antibody targeting the TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1). Mapatumumab exhibits anticancer activity, primarily by inducing tumor cell death through the activation of the death receptor-mediated apoptosis pathway. Mapatumumab is intended for use in cancer research.

Depatuxizumab is a humanised monoclonal antibody targeting EGFR with blood-brain barrier (BBB) permeability, capable of inhibiting the growth of xenograft tumours expressing mutant EGFR vIII and wild-type EGFR. It can be conjugated with the ADC molecule Depatuxizumab mafodotin for the study of glioblastoma (GBM) and head and neck squamous cell carcinoma (SCCHN).

Depatuxizumab MMAE is an antibody-drug conjugate (ADC) comprising the anti-EGFR monoclonal antibody depatuxizumab linked to the cytotoxic agent monomethyl auristatin E (MMAE). This ADC effectively suppresses the growth of xenograft models harboring both mutant EGFRvIII and wild-type EGFR [1].

Depatuxizumab mafodotin, an antibody-drug conjugate (ADC) targeting the epidermal growth factor receptor (EGFR), is utilized in cancer research [1].

Depatuxizumab-MMAF, an antibody-drug conjugate (ADC), comprises an EGFR-targeted antibody linked to McMMAF and is utilized in glioblastoma research.

Isopatulin can be isolated from marine-derived strains of the fungus Penicillium claviforme associated with the seagrass Zostera marina.

Neopatulin is an isomer involved in redox reactions and serves as a crucial biosynthetic precursor to the potent antibiotic patulin, which is produced by various fungi. It can be synthesized through a Lewis acid-catalyzed aldol condensation reaction or via the reaction of 2-formyl-1,3-dithiane with 2-(tert-butyldimethylsiloxy)-4-[(tert-butyldimethylsiloxy)methyl]furan.

Patulitrin has antioxidant, anti-inflammatory, and larvicidal activities, oral and topical administration of patuletin and patulitrin inhibited acute inflammation in mice.

Patuletin is a flavonol discovered in Tagetes patula that induces apoptosis in cancer cells such as CaSki, MDA-MB-231, and SK-Lu-1.

Epothilone B (EPO 906) is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Patupilone may cause complete cell-cycle arrest.

AKT-IN-25 (Compound 14a) is an inhibitor of Akt that prevents the phosphorylation of Akt, thereby hindering the PI3K/Akt/mTOR signaling pathway. It arrests the cell cycle at the G1 phase, inhibits the migration of PANC-1 cells, and suppresses the proliferation of cancer cells PANC-1, PATU-T, and SUIT-2, with IC50 values of 3.05, 1.32, and 3.85 μM, respectively.

Antitumor agent-165 (Compound 10l) is an effective inhibitor of focal adhesion kinase (FAK). It exhibits significant antiproliferative effects against CAPAN-1, PANC-1, PATU-T, SUIT-2, BxPC-3, PDAC-3, and PANC-1 GR cell lines, with IC50 values ranging from 1.04 to 3.44 μM.