pa-6

IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current) with an IC50 of 12-15 nM for human and mouse KIR2.x currents.

1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA is a phospholipid that contains arachidonic acid at the sn-1 position, serving as a precursor to 1-Monoarachidin. It binds with the LPA2/EDG4 receptor and can inhibit the secretion of TNF-α and IL-6 induced by LPS in wild-type dendritic cells but does not affect Lpa2-/- dendritic cells. Additionally, it reduces the differentiation of HT-29 human colon cancer cells into goblet cells in the presence of sodium butyrate.

1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) [1-Arachidonoyl-sn-glycerol 3-phosphate (sodium)] is a phospholipid containing arachidonic acid at the sn-1 position. It binds to the LPA2/EDG4 receptor with an EC50 of 10 nM and is present in the rat brain, representing 37% of arachidonic acid lysophosphatidic acid species. This compound serves as a precursor to 1-arachidonoyl-sn-glycerol and inhibits the secretion of TNF-α and IL-6 from dendritic cells stimulated by wild-type LPS. Additionally, 1-arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) can suppress the differentiation of HT-29 colon cancer cells into goblet cells in the presence of sodium butyrate.

Influenza virus-IN-6 (Compound 35) is a potent inhibitor of the N-terminal domain of the polymerase acidic protein (PA N) endonuclease subunit of the influenza virus, with an inhibitory concentration 50 (IC 50) value of 0.20 μM [1].

N-Acetyl-D-mannosamine-15N is the 15N-labeled version of N-Acetyl-D-mannosamine (ManNAc). This compound serves as an essential precursor for N-acetylneuraminic acid (NeuAc) and acts as a specific monomer in bacterial capsular poly(sialic acid) [PA]. N-Acetyl-D-mannosamine (ManNAc) is metabolized by GNE and GlcNAc 2-epimerase (renin-binding protein, RnBP) into ManNAc-6-phosphate and GlcN.

N-Acetyl-D-mannosamine-13C is the carbon-13 labeled version of N-Acetyl-D-mannosamine. N-Acetyl-D-mannosamine (ManNAc) is a critical precursor to N-acetylneuraminic acid (NeuAc) and plays a role as a specific monomer of bacterial capsular polysialic acid (PA). It is metabolized into ManNAc-6-phosphate and GlcN through the actions of GNE and GlcNAc 2-epimerase (renin-binding protein, RnBP).