ogerin

Ogerin is a selective GPR68 positive allosteric modulator (pEC50: 6.83) that blocks recall in fear conditioning in mice. It exhibits inverse agonist and antagonist activity (Ki, 220 nM) at the A2A receptor and weak antagonist activity (Ki, 736 nM) at the 5-HT2B receptor.

Progerinin (SLC-D011) is an orally active progerin-lamin A binding inhibitor that alleviates nuclear deformation and growth arrest, suitable for studying Hutchinson-Gilford progeria syndrome (HGPS).