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odc 1

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  • Inhibitors & Agonists
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    TargetMol | Inhibitors_Agonists
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L-Eflornithine
L-α-difluoromethylornithine, L-RMI71782, L-DFMO
T1181266640-93-5
L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 μM, and a Kinact of 0.15±0.03 min-1. L-Eflornithine is an enantiomer of Eflornithine.
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6-8 weeks
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L-Eflornithine monohydrochloride
L-α-difluoromethylornithine monohydrochloride, L-RMI71782 monohydrochloride, L-DFMO monohydrochloride
T11812L69955-42-6
L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 µM, and a Kinact of 0.15±0.03 min-1. L-Eflornithine monohydrochloride (L-DFMO monohydrochloride) is an enantiomer of Eflornithine.
    7-10 days
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    NCAO
    T20021520584-81-0
    N-ω-chloroacetyl-L-ornithine (NCAO) serves as a powerful reversible competitive inhibitor of ornithine decarboxylase (ODC), displaying cytotoxic and antiproliferative properties against various tumor cell lines, with EC50 values spanning from 1 to 50.6 µM. In vitro studies reveal that NCAO promotes Apoptosis and restricts tumor cell migration. Additionally, it demonstrates significant antitumor efficacy in a mouse model, targeting both solid and ascitic tumors using the myeloma (Ag8) cell line. NCAO holds promise in the development of antitumor agents.
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    4-6 weeks
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    Herbacetin
    T5S1331527-95-7
    1. Herbacetin induces apoptosis in HepG2 cells, by ROS and PI3K Akt pathway. 2. Herbacetin suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation.
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