ns2b-3

Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF.

Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.

1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has been used in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases.

DV-B-120 is a competitive inhibitor of the dengue virus (DENV). It inhibits the NS2B-NS3 protease, effectively targeting DENV-1, DENV-2, DENV-3, and DENV-4 with IC50 values of 5.35, 7.39, 10.49, and 8.58 μM, respectively. DV-B-120 exerts its antiviral effects by inhibiting DENV replication.

Agathisflavone is a NS2B-NS3 proteases inhibitor of the Dengue virus serotypes 2 and 3.

(E)-Guggulsterone is an isomer of guggulsterone. As an FXR antagonist, it reduces blood lipids, induces heme oxygenase-1 expression, blocks DENV NS2B/3B activity, and inhibits DENV replication.

NS2B/NS3-IN-3 (Compd 66) is a Flavivirus NS2B-NS3 protease inhibitor [1].

Palmatine hydroxide is an orally active, irreversible inhibitor of indoleamine 2,3-dioxygenase 1 (IDO-1), demonstrating IC50 values of 3 μM for HEK 293-hIDO-1 and 157μM for rhIDO-1. Additionally, it uncompetitively inhibits the West Nile virus (WNV) NS2B-NS3 protease with an IC50 of 96 μM. This compound exhibits a range of biological activities, including anti-cancer, anti-oxidation, anti-inflammatory, neuroprotective, antibacterial, and antiviral effects.

NS2B/NS3-IN-3 hydrochloride is a Flavivirus NS2B-NS3 protease inhibitor [1].

Theaflavin 3,3′-digallate (Standard) is a reference standard for research and analysis in studies involving Theaflavin 3,3′-digallate. Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF.

Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr is a substrate for the WNV NS2B-NS3 protease. It is utilized in the development of selective inhibitors for peptide substrates of the WNV NS2B-NS3 protease.