nomifensine

Nomifensine ((±)-Nomifensin) is a norepinephrine-dopamine reuptake inhibitor that prevents dopamine reuptake into synaptosomes.

Nomifensine maleate (Nomifensine (maleate)) is a selective inhibitor of dopamine uptake. Nomifensine maleate is used in adult attention deficit disorder.

1-Phenylbiguanide HCl, as 5-HT3 receptor agonists(3–100 μM, pEC50 5.05±0.06), acutely increased XII (hypoglossal) burst frequency and regularity, and decreased bursts/episode . 1-Phenylbiguanide HCl produced a dose-related (10-500 microM) increase in the release of dopamine (280-2000%). When nomifensine (5 microM) was included in the Ringer solution, the effect of 1-Phenylbiguanide HCl on the release of dopamine was ameliorated or inhibited.

DAM-001 (Z236004662) is a potent non-competitive allosteric inhibitor of the human dopamine transporter (hDAT). It exhibits an IC50 of 24.70 μM in the absence of the orthosteric inhibitor Nomifensine and 1.026 μM when Nomifensine is present.

Z1078601926 is an allosteric inhibitor of the human dopamine transporter (hDAT) and exhibits a synergistic effect when combined with Nomifensine [1].