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Results for "
nkp1339
" in TargetMol Product Catalog- Inhibitors & Agonists2
BOLD-100 free base
NKP-1339 free base ; IT-139 free base ; KP-1339 free base, NKP-1339 free base, KP-1339 free base, IT-139 free base
T72543783324-98-1
BOLD-100 free base (NKP-1339; IT-139), a ruthenium-based anticancer agent, inhibits stress-induced GRP78 upregulation, thus disrupting endoplasmic reticulum (ER) homeostasis. This action induces ER stress and unfolded protein response (UPR), interfering with the intricate relationship between ER-stress response, lysosome dynamics, and autophagy execution.
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NKP-1339
KP-1339, IT-139
TQ0016197723-00-5
NKP-1339 (IT-139) induces G2 M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway.
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