nedd8 activating enzyme (nae)

ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).

ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.

Pevonedistat (MLN4924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50=4.7 nM) with therapeutic potential for myelodysplastic syndromes (MDS) and antitumor activity.

TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).

NAE-IN-3 (compound 1) is a potent and highly selective non-covalent competitive inhibitor of NEDD8-activating enzyme (NAE) with an IC50 of 0.8 μM. It inhibits NAE by blocking the ATP binding site and demonstrates selectivity over related E1 enzymes UAE and SAE. NAE-IN-3 is applicable for cancer research.

NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 (IC50: 79 nM).

NAE-IN-M22 (NEDD8 inhibitor M22) is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo.