mycophenolic acid

Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.

Mycophenolic acid IV is a useful organic compound for research related to life sciences. The catalog number is T124275 and the CAS number is 74838-16-7.

Mycophenolic acid acyl-β-D-glucuronide (Acyl-MPAG) is a metabolite of mycophenolic acid (an immunosuppressant).

Mycophenolic acid sodium is a potent uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH) with an EC50 of 0.24 μM, exhibiting broad antiviral activity against RNA viruses, including influenza, along with immunosuppressive properties and antiangiogenic and antitumor effects [1][2].

Mycophenolic Acid-D3 Phenyl Glucuronide is a deuterated compound of Mycophenolic Acid Phenyl Glucuronide. Mycophenolic Acid Phenyl Glucuronide (T60104) has a CAS number of 31528-44-6. Mycophenolic acid glucuronide is the glucuronide metabolite of mycophenolic acid in human plasma.

Mycophenolic acid-D3 is a derivative of Mycophenolic acid. Mycophenolic acid (T1335) is a compound that reduces GTP level and impacts transcription elongation of RNA polymerase II (RNAP II), promotes proximal site use and reverses the effect of cordyceps on selective polyadenylation.

Mycophenolic Acid Impurity (5,7-dihydroxy-4-methylphthalide) is an an immunosuppresant drug and potent anti-proliferative, and can be used in place of the older anti-proliferative azathioprine. It is usually used as part of triple therapy including a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. It is also useful in research for the selection of animal cells that express the E. coli gene coding for XGPRT (xanthine guanine phosphoribosyltransferase).

Mycophenolic acid glucuronide is the glucuronide metabolite of mycophenolic acid in human plasma.

Mycophenolic acid-13C-D3 the 13C and deuterated compound of Mycophenolic acid (T1335). Mycophenolic acid has a CAS number of 24280-93-1. Mycophenolic acid is an inosine monophosphate dehydrogenase (IMPDH) inhibitor with anti-proliferative activity.

Mycophenolic acid (Standard) is the standard substance of Mycophenolic acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.

Mycophenolic acid-β-D-glucuronide (Standard) is a reference standard for research and analysis in studies involving Mycophenolic acid-β-D-glucuronide. Mycophenolic acid glucuronide is the glucuronide metabolite of mycophenolic acid in human plasma.

Mycophenolic Acid-13C-D3 (Standard) is a reference standard of Mycophenolic Acid-13C-D3 intended for quantitative analysis, quality control, and related biochemical research applications. Mycophenolic acid-13C-d3 the 13C and deuterated compound of Mycophenolic acid. Mycophenolic acid has a CAS number of 24280-93-1. Mycophenolic acid is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.

Mycophenolic Acid-Beta-D-Glucuronide-[13C,D3] (Standard) is a reference standard of Mycophenolic Acid-Beta-D-Glucuronide-[13C,D3] intended for quantitative analysis, quality control, and related biochemical research applications.

Mycophenolic Acid-D3 (Standard) is a reference standard of Mycophenolic Acid-D3 intended for quantitative analysis, quality control, and related biochemical research applications. Mycophenolic acid-d3 (Mycophenolate-d3) is a derivative of Mycophenolic acid. Mycophenolic acid is a compound that reduces GTP level and impacts transcription elongation of RNA polymerase II (RNAP II), promotes proximal site use and reverses the effect of cordyceps on selective polyadenylation.

Mycophenolic Acid-D3 Phenyl Glucuronide (Standard) is a reference standard of Mycophenolic Acid-D3 Phenyl Glucuronide intended for quantitative analysis, quality control, and related biochemical research applications.

3-Hydroxymycophenolic acid (Compound 5) is a microbial transformation product of Mycophenolic acid derived from Cunninghamella echinulata. It exhibits relatively low cytotoxicity toward AGS cells and fibroblasts. 3-Hydroxymycophenolic acid can be utilized in research on immune-mediated kidney diseases.

Mycophenolic acid phenolic β-D-glucoside is a biochemical reagent used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars, encompassing carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the function of glycans in biological systems. This field is closely linked to basic research, biomedicine, and biotechnology.

Methyl mycophenolate (Mycophenolic Acid Methyl Ester) is found in the marine fungus Phaeosphaeria spartinae. Methyl mycophenolate is the methyl ester form of mycophenolic acid.

Mycophenolate Mofetil (TM-MMF), an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydrogenase (IMPDH).

Methyl mycophenolate, a methyl ester of mycophenolic acid, serves as a precursor for synthesizing mycophenolic acid β-D-glucuronide and various phenolic glycosides. It exists as a racemic mixture comprising (E)- and (Z)-isomers, known as (E/Z)-Methyl mycophenolate.

IMPDH2-IN-4 (compound 2d) is a Mycophenolic acid analog and a selective IMPDH2 inhibitor with a Ki of 1.8 μM. It exhibits potent cytotoxic activity against osteosarcoma cancer cell lines. Additionally, IMPDH2-IN-4 demonstrates high affinity for VEGFR-2, CDK2, and IMPDH.

VX-148 is a novel, non-competitive IMPDH inhibitor with a K(i) value of 6 nM for IMPDH Type II enzyme. It is slightly more effective than mycophenolic acid and VX-497 in inhibiting the proliferation of primary human lymphocytes (IC(50) approximately 80 nM). The presence of exogenous guanosine can mitigate VX-148's inhibitory activity. Notably, VX-148 does not impede the proliferation of non-lymphocyte types such as fibroblasts, indicating selective inhibition of IMPDH activity. The compound exhibits oral bioavailability in rats and mice; oral administration of VX-148 inhibits the primary antibody response in mice in a dose-dependent manner, with an ED(50) of 38 mg/kg b.i.d. Additionally, in mice, VX-148 at a dosage of 100 mg/kg b.i.d. significantly prolongs skin graft survival time.

Mycophenolate Mofetil-D4 is a deuterated compound of Mycophenolate Mofetil. Mycophenolate Mofetil (T6293) has a CAS number of 128794-94-5. Mycophenolate mofetil, an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydrogenase (IMPDH).

Mycophenolate Mofetil (Standard) is a reference standard for research and analysis in studies involving Mycophenolate Mofetil. Mycophenolate Mofetil (TM-MMF), an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydrogenase (IMPDH).