mouse embryonic fibroblast cells

HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).

TAT-SAMβA, an RNAENFDRF (SAMβA) peptide conjugated to the TAT 47–57 protein-derived cell-penetrating peptide, acts as a selective antagonist of the Mfn1-βIIPKC association. It has been shown to protect mouse embryonic fibroblast cells (MEFs) from cytotoxicity induced by oxidative stress [1].

Spermine-15N2 (NSC 268508-15N2) is the 15N-labeled version of Spermine. This compound acts as a natural antioxidant and anti-inflammatory agent. Spermine is effective in inhibiting certain bacterial cultures, particularly strains of Staphylococcus aureus, and induces dose-dependent neurotoxicity in the striatum. It can reversibly inhibit DNA synthesis reactions, mixed lymphocyte reactions, and cytotoxic lymphocyte responses in primary cultures of mouse splenocytes. As a polyamine nitric oxide donor, Spermine tetrahydrochloride supplies nitric oxide to platelets and inhibits platelet activation in a concentration-dependent manner. This compound is present in mammalian tissues, plants, bacteria, ribosomes, and bacteriophages, and it can inhibit primary human embryonic lung fibroblast cells in vitro.

Tembetarine chloride is an alkaloid isolated from Tinospora cordifolia, known for its antibacterial properties. It exhibits mild cytotoxicity against mouse fibroblast cells (L929) and human embryonic kidney cells (HEK293), with IC50 values of 1245.33 μg/mL and 1642.81 μg/mL, respectively.