mmpl3

SQ109 (NSC-722041) is an effective inhibitor of the trypomastigote form of the parasite (IC50 = 50 nM). SQ109 is an antitubercular agent and targets MmpL3.

MmpL3-IN-2, an inhibitor targeting MmpL3, exhibits low cytotoxicity and moderate metabolic stability, making it suitable for tuberculosis research [1].

MmpL3-IN-3 (Compound 12), an MmpL3 inhibitor, exhibits potent anti-tuberculosis activity with a minimum inhibitory concentration (MIC) of 0.1 μM against H37Rv and demonstrates good metabolic stability in mouse liver microsomes. This compound is valuable for anti-tubercular research [1].

MmpL3-IN-1, also known as compound 32, is a highly effective inhibitor of Mycobacterial membrane protein large 3 (MmpL3). With an anti-tuberculosis activity exhibiting a minimum inhibitory concentration (MIC) of less than 0.016 μg mL in M. tuberculosis, MmpL3-IN-1 is a valuable compound for research on drug-resistant tuberculosis [1].

AU1235 is a Mycobacterium tuberculosis inhibitor.

C-215 is a novel inhibitor of mycobacterial membrane protein large 3 (MmpL3).

NITD-349 is an inhibitor of MmpL3. It shows highly potent anti-mycobacterial activity with MIC50 of 23 nM against virulent Mycobacterium tuberculosis H37Rv.

BM212 is an antimycobacterial compound.It inhibits the growth of laboratory and clinical isolate M. tuberculosis strains.

GSK366A is an anti-TB agent against Mycobacterium bovis BCG and Mycobacterium tuberculosis, targeting MmpL3 and inhibiting EchA6.

BM635 hydrochloride is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).

BM635 mesylate, an inhibitor of MmpL3, exhibited significant anti-Divergent bacterium effects, inhibiting and binding Divergent bacterium H37Rv with an MIC50 value of 0.6 μM. BM635 mesylate was able to significantly increase bioavailability compared to free BM635.

BM635 hydrochloride is an MmpL3 inhibitor that exhibits significant anti-Divergent bacteriophage effects, inhibiting the binding of Divergent bacteriophage H37Rv (MIC50: 0.08 μM). Exposure to BM635 hydrochloride was doubled in vivo compared to free BM635.

BM635 mesylate is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).

MSU-43085, an orally active MmpL3 inhibitor targeting Mycobacterium tuberculosis (Mtb), demonstrates effective inhibition of Mtb in an acute murine tuberculosis infection model. This compound is applicable in tuberculosis research [1].

IC2418 is an MmpL3 inhibitor, being active against drug-resistant Mycobacterium tuberculosis.

BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).