mm1.s

Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).

BRD9876 is a selective inhibitor of MM1S growth.

Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.

ZXH-1-161 TFA is a potent small molecule degrader that functions as a modulator of the Cereblon (CRBN) E3 ubiquitin ligase and targets the degradation of the GSPT1 protein, demonstrating anti-tumor potential in multiple myeloma (MM1.S cell line) research. ZXH-1-161 TFA inhibits the STAT3 signaling pathway, effectively suppressing tumor cell proliferation and inducing apoptosis. As an important tool compound in the field of molecular glues, ZXH-1-161 is commonly used in research related to targeted protein degradation and cancer mechanisms.

Biotinylated-JQ1 is a biotin-labeled probe that binds specifically to BRD2/3/4. It can be used for activity assays, functional studies, and binding affinity analysis in epigenetic research.

ZXH-4-130 TFA is a hetero-PROTAC (CRBN-VHL compound) that efficaciously and selectively mediates the degradation of CRBN, achieving approximately 80% degradation at a concentration of 10 nM in MM1.S cells [1].