minocycline

Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochloride can cause both an acute hepatitis-like syndrome occurring within 1 to 3 months of starting therapy or a more insidious chronic hepatitis with autoimmune features typically after long-term treatment.

Minocycline is a broad-spectrum and highly lipophilic tetracycline antibiotic with the advantages of being orally administrable and able to penetrate the blood-brain barrier. It binds to the 30S ribosomal subunit to inhibit protein synthesis, is effective against both Gram-positive and Gram-negative bacteria, and also has neuroprotective, anti-inflammatory, and antioxidant effects.

10-Butyl EtherMinocycline is a derivative of Minocycline and acts as an inhibitor of MMP-8 and MMP-9, with IC50 values of 69.4 µM and 47.0 µM, respectively. It exhibits negligible antibacterial activity against E. coli, S. typhi, and C. albicans. Additionally, 10-Butyl EtherMinocycline inhibits LPS-induced microglial activation and VEGF-induced endothelial cell migration, as well as L-Glutamine-induced ROS levels. This compound significantly reduces alcohol consumption in a chronic intermittent ethanol (CIE) mouse model and is utilized in studies related to neuroinflammation and alcohol use disorder (AUD).

4-epiMinocycline, recognized as a primary degradation product and a probable impurity in minocycline commercial formulations, is derived from minocycline, a broad-spectrum tetracycline antibiotic notable for its extended serum half-life. Besides treating acne, especially in older patients, minocylvania exhibits significant anti-inflammatory and neuroprotective effects.

Minocycline-D6 sulfate is the deuterium-labeled form of Minocycline. Minocycline itself is a semisynthetic tetracycline antibiotic that is effective orally and can cross the blood-brain barrier, acting as an HIF-1α inhibitor. It possesses bacteriostatic, anti-cancer, anti-inflammatory, neuroprotective, and antidepressant properties.

Minocycline hydrochloride (Standard) is the standard substance of Minocycline hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Minocycline hydrochloride (Minocycline HCl) belongs to the tetracycline group of antibiotics with excellent absorption and tissue penetration. Minocycline hydrochloride is a broad-spectrum antimicrobial agent used for a wide range of bacterial infections as well as acne treatment.

Minocycline-[D6] Hydrochloride (Standard) is a reference standard of Minocycline-[D6] Hydrochloride intended for quantitative analysis, quality control, and related biochemical research applications.