mglu2/3 receptor

LY404039 (pomaglumetad) is an effective agonist of recombinant human mGlu2(Ki =149 nM) mGlu3(Ki =92 nM).

LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2 3 receptor (mGlu2 3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM.

Eglumegad is a highly effective and selective agonist of group II (mGlu2/3) receptor (IC50s: 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively).

LY389795 is an agonist of group II (mGlu2/3) metabotropic glutamate receptor, it is used in inflammatory pain models.

LY2934747 is a novel, potent, and systemically bioavailable mGlu2 3 receptor agonist, exhibiting both antipsychotic and analgesic properties in vivo.

LY3027788, a diester analog of LY3020371 and an mGlu2 3 receptor antagonist, is a highly potent, orally active prodrug of LY3020371 with notable antidepressant efficacy.

CBiPES hydrochloride (CBiPES HCl) is a potent orthosteric modulator of the mGlu2 receptor with an EC50 value of 92.8 nM.CBiPES hydrochloride blocks the action of WT and mGlu(3) receptors.CBiPES hydrochloride can be used to study neurological disorders like epilepsy and Parkinson's syndrome. CBiPES hydrochloride can be used to study neurological disorders like epilepsy and Parkinson's syndrome.

Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2 3 receptor LY404039.

Pomaglumetad methionine hydrochloride (LY2140023 hydrochloride) is a methionine prodrug of LY404039 with oral activity. LY404039 is a selective mGlu2 3 receptor agonist. Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) has research value in schizophrenia.

Eglumegad (LY354740) hydrochloride is a potent, selective agonist for group II (mGlu2 3) receptors, showing IC50 values of 5 nM for mGlu2 and 24 nM for mGlu3 receptors in transfected human cells. This compound provides neuroprotection against NMDA-induced toxicity and exhibits anxiolytic- and antipsychotic-like properties [1].