mg1

ARRY-403, also known as AMG-151, is an orally available allosteric glucokinase (GK) activator developed for the treatment of type 2 diabetes mellitus (T2DM). ARRY-403 has many favorable physicochemical characteristics and ADME properties (low potential to cause drug–drug interactions (DDIs). ARRY-403 potently activates human glucokinase (GK) in vitro (EC50 = 79 nM at 5 mM glucose), with an S0.5 = 0.93 mM glucose (ARRY-403 at 5 mM) and Vmax = 134% compared to the no activator control. It possesses good in vitro drug-like properties (aqueous solubility, cell permeability, low low potential for drug-drug interactions, low predicted hepatic clearance), and selectivity against broad panels of receptors and enzymes.

CDMG1 is a novel Wnt inhibitor, promoting heart regeneration, injury repair, and myocardial hyperplasia through expansion of the cardiac progenitor cell population

AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for the treatment of type 2 diabetes mellitus (non-insulin dependent diabetes)

Anti-Mouse IFN gamma Antibody (XMG1.2) is a rat IgG1 kappa monoclonal antibody specifically targeting IFNγ in mice. The recommended isotype control for this antibody is Rat IgG1 kappa, Isotype Control.

AMG133 peptide payload serves as a GLP-1 agonist and is utilized as a peptide linker conjugate for AMG133.

AMG133 peptide payloadTFA is the trifluoroacetic acid (TFA) salt form of AMG133 peptide payload. This compound acts as a GLP-1 agonist and serves as a peptide-linker conjugate, which is utilized in the synthesis of AMG133.

MG 1 is a potent alpha-1 adrenergic receptor antagonist.

Linearmycin A is a polyene antibiotic found in [Streptomyces]. It exhibits activity against bacteria [S. aureus] and [E. coli] (MICs = 3.1 and 1.6 μg disc, respectively), fungi [S. cerevisiae] and [C. albicans] (MICs = 0.1 and 1.6 μg disc, respectively), and the plant pathogenic fungus [A. niger] (MIC = 0.2 μg disc) in disc assays. Linearmycin A also induces lysis and degradation of [B. subtilis] as a component of [Streptomyces Mg1] extract.

Anti-mouse ICOSL CD275 antibody, targeting ICOSL CD275.