metalloenzyme

Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.

CG347B is a selective inhibitor of HDAC6.

AubipyOMe serves as an effective inhibitor of Tartrate-resistant Acid Phosphatase (TRAP ACP5), a metalloenzyme identified in activated osteoclasts and macrophages. It exhibits inhibitory IC50 values of 1.3 μM against TRAP5a and 1.8 μM against TRAP5b. Additionally, it effectively suppresses TRAP activity in extracts from mouse macrophages and human lung tissues.

ts-SA is a metalloenzyme carbonic anhydrase (CA) inhibitor. It is active against 7 out of 10 human CA isoforms.

Tyrosinase-IN-2 (compound 67) is a potent inhibitor of tyrosinase, a copper-containing metalloenzyme crucial for the rate-limiting step in melanin biosynthesis and enzymatic browning processes. This compound shows promise for research into skin whitening agents and food preservatives [1].

Tyrosinase-IN-3 (compound 54) is a potent inhibitor of tyrosinase, a copper-containing metalloenzyme essential in melanin biosynthesis and enzymatic browning, showing potential for research in skin whitening agents and food preservatives [1].

Carbonic anhydrase is a ubiquitous, zinc-containing metalloenzyme found in both prokaryotes and eukaryotes. It catalyzes the reversible conversion of carbon dioxide to bicarbonate and protons and can be used for research in cancer, glaucoma, obesity, and epilepsy [1] [2].

Galactose oxidase (GOase), a type II copper metalloenzyme derived from fungus, comprises a single polypeptide. It is commonly utilized in biochemical studies for catalyzing the two-electron oxidation of primary alcohols to aldehydes, simultaneously reducing dioxygen to hydrogen peroxide [1].