metalloenzyme

CG347B is a selective inhibitor of HDAC6.

Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.

AubipyOMe serves as an effective inhibitor of Tartrate-resistant Acid Phosphatase (TRAP/ACP5), a metalloenzyme identified in activated osteoclasts and macrophages. It exhibits inhibitory IC50 values of 1.3 μM against TRAP5a and 1.8 μM against TRAP5b. Additionally, it effectively suppresses TRAP activity in extracts from mouse macrophages and human lung tissues.

ts-SA is a metalloenzyme carbonic anhydrase (CA) inhibitor. It is active against 7 out of 10 human CA isoforms.

Tyrosinase-IN-2 (compound 67) is a potent inhibitor of tyrosinase, a copper-containing metalloenzyme crucial for the rate-limiting step in melanin biosynthesis and enzymatic browning processes. This compound shows promise for research into skin whitening agents and food preservatives [1].

Tyrosinase-IN-3 (compound 54) is a potent inhibitor of tyrosinase, a copper-containing metalloenzyme essential in melanin biosynthesis and enzymatic browning, showing potential for research in skin whitening agents and food preservatives [1].

Carbonic anhydrase is a class of zinc-containing enzymes that efficiently catalyze the reversible hydration of carbon dioxide. Carbonic anhydrase is used in research on cancer, glaucoma, obesity, and epilepsy.

Galactose oxidase (GOase), a type II copper metalloenzyme derived from fungus, comprises a single polypeptide. It is commonly utilized in biochemical studies for catalyzing the two-electron oxidation of primary alcohols to aldehydes, simultaneously reducing dioxygen to hydrogen peroxide [1].

Carbonic Anhydrase, Human (EC 4.2.1.1), is a zinc metalloenzyme that catalyzes the hydration of carbon dioxide to form carbonic acid. It plays a role in various essential physiological processes, such as maintaining pH and carbon dioxide homeostasis, transporting bicarbonate and carbon dioxide, biosynthetic reactions, bone resorption, calcification, and tumorigenesis.

D-Ribulose-5-phosphate 3-Epimerase, derived from Baker's yeast (S. cerevisiae) (EC 5.1.3.1), is a metalloenzyme that primarily uses divalent zinc ions (Zn2+) for catalysis.

Carbonic Anhydrase I, Human (EC 4.2.1.1), is a zinc metalloenzyme that catalyzes the hydration of carbon dioxide to form carbonic acid. This enzyme plays a crucial role in various physiological processes, including maintaining pH and carbon dioxide homeostasis, transporting bicarbonate and carbon dioxide, facilitating biosynthetic reactions, bone resorption, calcification, and tumor progression.