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Results for "

metallo-β-lactamase ndm-1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    19
    TargetMol | Inhibitors_Agonists
  • Recombinant Protein
    1
    TargetMol | Recombinant_Protein
IMB-XH1
Mcl1-IN-2
T16028292057-76-2
IMB-XH1 (Mcl1-IN-2) is a myeloid cell factor 1 (Mcl-1) inhibitor.
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TargetMol | Inhibitor Sale
Metallo-β-lactamase-IN-16
T2010212058069-25-1
Metallo-β-lactamase-IN-16 (compound 18), a sulfone-containing metallo-β-lactamase inhibitor, exhibits antimicrobial activity. It effectively inhibits various metallo-β-lactamases, including NDM-1 (New Delhi metallo-β-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona Integron-encoded Metallo-β-lactamase), and VIM-2. The IC50 values for these enzymes are 0.16 nM, 0.23 nM, 0.31 nM, and 1.0 nM respectively.
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3-6 months
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NDM-1 inhibitor-8
T204912
NDM-1 inhibitor-8 (Compound 18b) is a covalent inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1), with an IC50 of 7.03 μM. It effectively inhibits resistant bacterial strains and demonstrates synergistic antibacterial effects when used in combination with Meropenem. In mouse models, NDM-1 inhibitor-8 exhibits anti-infective activity.
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NDM-1 inhibitor-1
T2814880570-90-7
NDM-1 inhibitor-1 is an inhibitor of new delhi metallo-β-lactamase-1 (NDM-1).
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6-8 weeks
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NDM-1 inhibitor-2
NDM1 inhibitor2,NDM 1 inhibitor 2
T28149665013-76-3
NDM-1 inhibitor-2 is an inhibitor of new delhi metallo-β-lactamase-1 (NDM-1).
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6-8 weeks
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Metallo-β-lactamase-IN-3
T60282128294-71-3
Metallo-β-lactamase-IN-3 (compound 35) is a potent metallo-β-lactamases (MBL) inhibitor that can potentially restore the activity of current β-lactam antibiotics and provide an orthogonal strategy for discovering new antibiotics. It exhibits high activity against VIM-1 and NDM-1, with IC50 values of 0.6 and 1.0 μM, respectively, but does not inhibit IMP-7 [1].
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6-8 weeks
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Metallo-β-lactamase-IN-2
T603701501705-61-8
Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamase (MBL) inhibitor with IC50 values of 0.1 μM for VIM-1, 1.3 μM for NDM-1, and 5.0 μM for IMP-7, respectively [1].
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6-8 weeks
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Captopril hydrochloride
T60383198342-23-3
Captopril (SQ 14225) hydrochloride is an antihypertensive agent that is a thiol-containing, competitive, orally active angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 0.025 μM, widely used in hypertension and congestive heart failure research. It is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM [1] [2] [3].
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1-2 weeks
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NDM-1 inhibitor-3
T60454
NDM-1 inhibitor-3 is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor (Ki : 4 μM) widely found in nature and is associated with antibiotic resistance.
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10-14 weeks
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Metallo-β-lactamase-IN-4
T606942711044-25-4
Metallo-β-lactamase-IN-4 (compound 40) is a potent inhibitor of metallo-β-lactamases (MBL) with IC50 values of 0.5 μM for VIM-1, 2.1 μM for NDM-1, and 3.3 μM for IMP-7, respectively [1].
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6-8 weeks
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Metallo-β-lactamase-IN-5
T611731417737-65-5
Metallo-β-lactamase-IN-5 (compound 5c) is a potent inhibitor of metallo-β-lactamases (MBLs), demonstrating inhibitory activity against MBLs NDM-1 and VIM-1. It effectively inhibits HUVECs with an IC50 value of 45 μg mL. Additionally, when combined with Imipenem, Metallo-β-lactamase-IN-5 exhibits synergistic antimicrobial activity [1].
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6-8 weeks
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MßL-IN-2I
T69482305376-89-0
MßL-IN-2I is a potent broad-spectrum metallo-β-lactamase (MβL) inhibitor which inhibits the MβLs NDM-1, VIM-2, ImiS, and L1.
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6-8 weeks
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Metallo-β-lactamase-IN-9
T722611802363-75-2
Metallo-β-lactamase-IN-9 (Compound 23) is a broad-spectrum inhibitor of metallo-beta-lactamases (MBL), with inhibition constants (IC50) of 35 nM for NDM-1, 269 nM for VIM-1, and 369 nM for IMP-1 [1].
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6-8 weeks
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EBL-3183
T74849
EBL-3183, an indole-2-carboxylate, is a potent, reversible, non-covalent, competitive inhibitor of metallo-β-lactamase (MBL), specifically targeting NDM-1 with a pIC50 of 7.7 [1].
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Metallo-β-lactamase-IN-11
T79435
Metallo-β-lactamase-IN-11 (compound 5f), a potent inhibitor of Metallo-β-lactamases (MBLs), demonstrates efficacy against bacterial metallophyllactamase CphA with an IC50 value of 45 µM. At 10 µM, it inhibits NDM-1 by 49% and AIM-1 by 61%, indicating its potential for research on countering antibiotic resistance [1].
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Zndm19
T80721364055-05-0
Zndm19 is an inhibitor of New Delhi Metallo-β-lactamase-1 (NDM-1), utilized in researching drug-resistant bacterial infections [1].
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8-10 weeks
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YJ196
T80754
Compound YJ196 (Compound 59) serves as an inhibitor of New Delhi Metallo-β-lactamase-1 (NDM-1) [1].
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MBL-IN-3
T868661452395-68-4
MBL-IN-3 (compound 72922413), a potent inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1) with an IC50 value of 54±4 μM, effectively reduces the minimum inhibitory concentrations (MICs) of Meropenem against clinical isolates of E. coli and K. pneumoniae that express NDM-1. This compound is utilized in studies focused on antibiotic sensitizer research [1].
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10-14 weeks
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Metallo-β-lactamase-IN-15
T868851804934-57-3
Metallo-β-lactamase-IN-15 (Compound ±13), a potent inhibitor of MBL, demonstrates IC 50 values of 0.29 μM for NDM-1, 0.088 μM for IMP-1, and 0.063 μM for VIM-2, respectively [1].
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10-14 weeks
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