metabolized — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0505	Methyldopa	L-(-)-α-Methyldopa,MK-351	Dopamine Receptor , Adrenergic Receptor
	Methyldopa (MK-351), an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive medicine, is served as an antihypertensive or sympatholytic.		Dopamine Receptor , Adrenergic Receptor
T5954	Methyldopa hydrate	Alpha-Methyldopa Sesquihydrate,L-(-)-α-Methyldopa hydrate,MK-351 hydrate,Methyldopa Sesquihydrate	Dopamine Receptor , Adrenergic Receptor
	Methyldopa hydrate (MK-351 hydrate) is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension. It inhibits the sympathetic nervous system, decreases production of dopamine, ...		Dopamine Receptor , Adrenergic Receptor
T3397	Epmedin C	Baohuoside-VI,Epimedin C	Others
	Epmedin C (Baohuoside-VI) was metabolized via desugarization, dehydrogenation, hydrogenation, dehydroxylation, hydroxylation, demethylation and glucuronidation pathways in vivo. It has potential activity against osteopor...		Others
T10989	Dehydroaripiprazole	OPC-14857,DM-14857	5-HT Receptor
	Dehydroaripiprazole (DM-14857) is the active metabolite of aripiprazole. Aripiprazole is an antipsychotic drug, which is metabolized by CYP3A4 and CYP2D6 and mainly forms dehydroaripiprazole. Dehydroaripiprazole has anti...		5-HT Receptor
T7433	2-Phenylethylamine hydrochloride	&beta,-Phenylethylamine hydrochloride,benzeneethanamine hydrochloride,&beta,-aminoethylbenzene hydrochloride	Others
	2-Phenylethylamine hydrochloride (benzeneethanamine hydrochloride) acts as neuromodulator in the central nervous system. It stimulates the release of norepinephrine and dopamine and is metabolized by monoamine oxidases a...		Others
T12490	Pitavastatin lactone		Others
	Pitavastatin lactone is a major Pitavastatin metabolite in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes.		Others
T10618	Broflanilide		GABA Receptor
	Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR (IC50: 1.3 nM).		GABA Receptor
T4898	Potassium 1-carboxyvinyl hydrogenphosphate	PEP-K,Phospho(enol)pyruvic acid monopotassium	Others , Endogenous Metabolite
	Potassium 1-carboxyvinyl hydrogenphosphate (PEP-K) is involved in glycolysis and gluconeogeneis. In glycolysis, PEP is metabolized by Pyruvate Kinase to yield pyruvate. In plants, PEP is involved in the formation of arom...		Others , Endogenous Metabolite
T22025	AG 045572		P450 , GNRH Receptor
	AG 045572 is a potent GnRH receptor antagonist that inhibits the GnRH receptor in humans and rats with Ki values of 6.0 nM and 3.8 nM, respectively.AG 045572 is metabolized by CYP3A and inhibits testosterone.		P450 , GNRH Receptor
T5064	Oxalic acid dihydrate	Ethanedioic acid dihydrate	Others , Endogenous Metabolite
	Oxalic acid dihydrate (Ethanedioic acid dihydrate) is a strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized...		Others , Endogenous Metabolite
T19676	Tributyrin	NSC661583,NSC 661583,NSC-661583	Apoptosis
	Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed prodrug of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracell...		Apoptosis
T0816	Acetohexamide	Acetohexamid,Dymelor,Gamadiabet	Potassium Channel , NADPH
	Acetohexamide (Acetohexamid) is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2) wi...		Potassium Channel , NADPH
T77562	Methyl-a-L-fucopyranoside	Methyl alpha-L-fucopyranoside	Antifungal
	Methyl-a-L-fucopyranoside (Methyl alpha-L-fucopyranoside) is a rhizobial lectin inhibitor that is not metabolized by the fungus and prevents the biocontrol agent Trichoderma reesei from coiling around the rhizobial mycel...		Antifungal
T1273	Diacerein	Diacerhein,Fisiodar,Diacetylrhein	IL Receptor , Interleukin
	Diacerein (Fisiodar) is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including sevre ...		IL Receptor , Interleukin
T1266	Terfenadine	(±)-Terfenadine,MDL-991	Apoptosis , Potassium Channel , 5-HT Receptor , Caspase , Na+/Ca2+ Exchanger , HER , AChR , Histamine Receptor
	Terfenadine ((±)-Terfenadine) is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects.
T3662	Eleutheroside E		NF-κB
	Eleutheroside E has anti-inflammatory effects by inhibiting NF-κB activities. Eleutheroside E significantly decreases the inflammatory cell infiltration, pannus formation, cartilage damage, bone erosion of CIA mice, the ...		NF-κB
T0522	Diammonium Glycyrrhizinate	Glycyrrhizin	Dehydrogenase
	Diammonium Glycyrrhizinate (Glycyrrhizin) , an extensively used anti-inflammatory agent, is isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inhibits 11-β-hydroxysteroid dehydrogenase and ...		Dehydrogenase
T15773	Lofepramine	Gamanil,Amplit,Leo 640,Lopramine	5-HT Receptor , Norepinephrine
	Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, ...		5-HT Receptor , Norepinephrine
T2A2532	L-Histidine	Glyoxaline-5-alanine,L-(-)-Histidine,histidine,L-Hisidine	Mitochondrial Metabolism , Endogenous Metabolite
	L-Histidine (L-(-)-Histidine) is a semi-essential amino acid (children should obtain it from food) needed in humans for growth and tissue repair, L-Histidine is important for maintenance of myelin sheaths that protect ne...		Mitochondrial Metabolism , Endogenous Metabolite
T1408	Capecitabine	Xeloda,Capecitibine,Capiibine,RO 09-1978	Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
	Capecitabine (Capecitibine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moie...