mental disorders

Triflupromazine is a dopamine receptor D1 D2 antagonist and LHDA inhibitor that suppresses dopamine activity in the central nervous system (CNS) and promotes LDHA-mediated AMBRA1 ubiquitination, used for treating mental disorders, sedation, and antiemesis.

GSK3-IN-9 (0713) is a selective inhibitor of glycogen synthase kinase 3 (GSK3). It holds potential for research into fragile X syndrome, attention deficit hyperactivity disorder (ADHD), childhood epilepsy, intellectual disabilities, diabetes, acute myeloid leukemia (AML), autism, and mental disorders.

AZD1134 is an orally active, brain-penetrant, and highly selective 5-HT1B receptor antagonist with IC50 values of 2.9 nM (human) and 0.108 nM (guinea pig). It elevates synaptic serotonin levels in guinea pigs and holds potential for research in mental disorders such as depression and anxiety.

Cycrimine is an orally active antagonist of the muscarinic cholinergic receptor (mAChR) M1 that reduces the level of acetylcholine in the Parkinson's model. Cycrimine exhibits antispasmodic activity that can be used in behavioral and mental disorders research [1] [2] [3] [4].

Methylpiperic acid, a piperine alkaloid, exhibits potent inhibitory activity on monoamine oxidase (MAO), with differing efficacy on isoforms: greater inhibition of MAO-A (IC 50 27.1 μM) compared to MAO-B (IC 50 1.6 μM), indicative of its bidirectional inhibition. Moreover, it is applied in the treatment of mental disorders [1].

Compound 42, also known as M1/M2/M4 muscarinic agonist 1, is a muscarinic M4/M1/M2 agonist exhibiting EC50 values of 6.5, 26, and 210 nM for M4, M1, and M2 respectively. This compound is utilized in research focused on mental disorders, including schizophrenia and delusion [1].

CID44216842 (KUC103479N-02) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 0.3 and 0.5 μM in GDP binding assay, respectively. Use as a molecular probe.