melanoma xenografts

CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway.

Tubulin-IN-54 is a tubulin inhibitor exhibiting antiproliferative effects against various cancer cell lines. It disrupts microtubule assembly, leading to the breakdown of the microtubule network, inducing G2/M phase cell cycle arrest, and promoting apoptosis in cancer cells. Additionally, Tubulin-IN-54 demonstrates significant antitumor efficacy in mice with PC-3/TxR xenografts. It is applicable in studies of paclitaxel-resistant cancers, such as prostate cancer and melanoma.

XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50: 24 nM). Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis. Through this action, specific clie

ARN22089 is an oral active CDC42 GTPase interaction inhibitor that blocks tumour growth in BRAF mutant mouse melanoma models and patient-derived xenografts (PDXs) in vivo.