md2-tlr4

MD2-TLR4-IN-1 is a myeloid differentiation protein 2 toll-like receptor 4 (MD2-TLR4) complex inhibitor.

Neoseptin-3 is a novel small molecule agonist of mouse mTLR4 MD2 with EC50=18.5 μM that does not activate human TLR4 MD2.

1Z105, an orally active TLR4 MD2 ligand, facilitates dendritic cell maturation and antigen presentation, thereby preventing arthritis.

L48H37 is a chemically stable analog of Curcumin. It exhibits potent inhibitory properties against myeloid differentiation protein 2 (MD2), acting as a specific inhibitor. Its mechanism involves inhibiting the interaction and signaling transduction of LPS-TLR4 MD2. L48H37 is primarily utilized in sepsis and lung injury research [1].

Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4 MD-2 complex and has anti-inflammatory activity.