mcmv

Tomeglovir is a potent anti-CMV agent, inhibiting the processing of viral DNA-concatemers (IC50s: 0.34/0.039 μM for HCMV and MCMV).

LDC4297 hydrochloride is a selective and efficient CDK7 inhibitor with broad-spectrum antiviral activity. It inhibits herpesvirus, adenovirus, poxvirus, retrovirus, and positive-strand RNA viruses. It can be used for research on viral infections.

PNU-183792 is a 4-oxo-1,4-dihydroquinoline that acts as an orally active inhibitor of herpesvirus polymerases (HSV polymerases). It exhibits broad-spectrum antiviral activity, with IC50 values of 0.69 μM for human cytomegalovirus (HCM), 0.37 μM for varicella-zoster virus, and 0.58 μM for herpes simplex virus (HSV) polymerase. PNU-183792 shows no activity against human α, γ, and δ polymerases but inhibits simian varicella virus (SVV), murine cytomegalovirus (MCMV), and rat cytomegalovirus (RCMV).

PMEG is an inhibitor targeting the nuclear DNA polymerases α, δ, and ε (DNA polymerases α/δ/ε), leading to DNA chain termination and suppression of DNA synthesis, which induces cytotoxicity in proliferating cells. This acyclic nucleoside phosphonate converts intracellularly to its active phosphorylated metabolite, PMEG diphosphate. In rodent models, PMEG demonstrates activity against leukemia and melanoma. Due to its poor cellular permeability, its prodrug form is known as Rabacfosadine (GS-9219). PMEG exhibits antiviral activity against several DNA virus infections, including murine cytomegalovirus (MCMV) and human cytomegalovirus (HCMV). It is also investigated for non-Hodgkin's lymphoma research.

PMEDAP is a potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and mortality, as well as a human immunodeficiency virus (HIV) replication inhibitor with anti-murine cytomegalovirus (MCMV) activity.