Shopping Cart
Remove All
Your shopping cart is currently empty
PMEG
(Synonyms: 9-(2-Phosphonylmethoxy)ethylguanine) Copy Product Info
🥰Excellent
Synonyms: 9-(2-Phosphonylmethoxy)ethylguanine
Catalog No. T217752 Copy Product Info
🥰Excellent
PMEG is an inhibitor targeting the nuclear DNA polymerases α, δ, and ε (DNA polymerases α/δ/ε), leading to DNA chain termination and suppression of DNA synthesis, which induces cytotoxicity in proliferating cells. This acyclic nucleoside phosphonate converts intracellularly to its active phosphorylated metabolite, PMEG diphosphate. In rodent models, PMEG demonstrates activity against leukemia and melanoma. Due to its poor cellular permeability, its prodrug form is known as Rabacfosadine (GS-9219). PMEG exhibits antiviral activity against several DNA virus infections, including murine cytomegalovirus (MCMV) and human cytomegalovirus (HCMV). It is also investigated for non-Hodgkin's lymphoma research.
PMEG
Cas No. 114088-58-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Quotation
For research use only—not for human use. No sales to individuals. Use as intended only.
Resource Download
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PMEG is an inhibitor targeting the nuclear DNA polymerases α, δ, and ε (DNA polymerases α/δ/ε), leading to DNA chain termination and suppression of DNA synthesis, which induces cytotoxicity in proliferating cells. This acyclic nucleoside phosphonate converts intracellularly to its active phosphorylated metabolite, PMEG diphosphate. In rodent models, PMEG demonstrates activity against leukemia and melanoma. Due to its poor cellular permeability, its prodrug form is known as Rabacfosadine (GS-9219). PMEG exhibits antiviral activity against several DNA virus infections, including murine cytomegalovirus (MCMV) and human cytomegalovirus (HCMV). It is also investigated for non-Hodgkin's lymphoma research. |
| In vivo | Rabacfosadine (GS-9219) administered intravenously at doses of 0.20-0.82 mg/kg over 30 minutes can significantly accumulate PMEG in lymphoid cells, leading to a remission rate of 79% in domestic dogs with spontaneous non-Hodgkin's lymphoma. |
| Synonyms | 9-(2-Phosphonylmethoxy)ethylguanine |
| Molecular Weight | 289.19 |
| Formula | C8H12N5O5P |
| Cas No. | 114088-58-3 |
| Smiles | O=C1N=C(N)NC2=C1N=CN2CCOCP(=O)(O)O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: PMEG in vivo | PMEG formula | PMEG molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.