mchr1 antagonist 1

MCHR1 antagonist 1 is a selective antagonist of the melanin-concentrating hormone-1 (MCH1) receptor with a Kb of 1 nM and a Ki of 4 nM at the human MCH1 receptor.

MCHR1 antagonist 2 is an inhibitor of melanin-concentrating hormone receptor 1 (MCH1-R, IC50 = 65 nM) and also inhibits hERG.

MCHR1 antagonist 3, a potent antagonist of the melanin-concentrating hormone receptor-1 (MCHR1), is employed for the regulation of energy metabolism.

MCHR1antagonist 4 (Compound 2m) is an MCHR1 antagonist capable of penetrating the blood-brain barrier, with Ki values of 0.74 nM and 0.76 nM for hMCHR1 and rMCHR1, respectively. Additionally, it serves as an effective anti-obesity agent.

SNAP 94847 hydrochloride is a melanin-concentrating hormonereceptor1 (MCHR1) antagonist(Ki= 2.2 nM)

AZD1979 is a highly potent MCHR1 (Melanin-concentrating hormone receptor 1) antagonist with an IC50 of 12 nM, exhibiting improved central nervous system (CNS) exposure and enhanced insulin sensitivity in steady-state model assessments, making it suitable for the treatment of obesity.

BMS-819881, a melanin-concentrating hormone receptor 1 (MCHR1) antagonist, binds rat MCHR1 with a Ki of 7 nM, and is selective and potent for CYP3A4 activity with an EC50 of 13 μM.

NGD-4715 is a selective, orally active antagonist of melanin-concentrating hormone receptor 1 (MCHR1).

T-226296 is a antagonist of melanin concentrating hormone receptor 1 (MCHR1).

ATC0065 dihydrochloride is a novel nonpeptidic and potent melanin-concentrating hormone receptor 1 (MCHR1) selective antagonist.