manumycin a

Manumycin A is an antibiotic with anticancer activity and is a mammalian thioredoxin reductase-1 (TrxR-1) inhibitor.Manumycin A inhibits the production of IL-1β, IL-6, and IL-8 in TNF alpha-stimulated THP-1 cells and peripheral blood mononuclear cells in a dose-dependent manner, inducing apoptosis.

Manumycin F exhibits activity against Gram-positive bacteria and Escherichia coli, though it is largely ineffective against other Gram-negative bacteria and shows no antifungal properties. It inhibits RAS farnesyltransferase and demonstrates limited cytotoxicity against the human colon cancer cell line [HCT-116].

Manumycin G exhibits activity against Gram-positive bacteria and Escherichia coli, but shows limited effectiveness against other Gram-negative bacteria and no activity against fungi. The compound inhibits RAS farnesyltransferase and possesses moderate cytotoxic activity against the human colon cancer cell line [HCT-116].

Manumycin E exhibits activity against Gram-positive bacteria and Escherichia coli, but has limited effect on other Gram-negative bacteria and none on fungi. It inhibits RAS farnesyltransferase and demonstrates modest cytotoxic activity against the human colorectal cancer cell line [HCT-116].