m133

M133 is a selective histone deacetylase HDAC1 and HDAC2 inhibitor and potent antitumor agent.

The M133 peptide is a coronavirus-specific CD4 T cell epitope. In mice infected with the neurotropic coronavirus (strain JHM of mouse hepatitis virus), the M133 peptide demonstrates immunodominance. It activates CD4 T cells by forming an MHC/peptide complex through binding with MHC II molecules, which is recognized by specific TCRs.

Pefabloc is an irreversible serine proteinase inhibitor. Pefabloc efficiently inhibits both human and rat platelet activating factor (PAF)-degrading acetylhydrolase (acetylhydrolase).

UCM-1336 (3,3′-(Octylimino)bis[N-phenylpropanamide]) is a potent ICMT inhibitor with an IC50 of 2 μM which is selective against the other enzymes involved in the post-translational modifications of Ras.

Abacavir hydroxyacetate is an orally active nucleoside analog reverse transcriptase inhibitor. It has anti-HIV and immunomodulatory activity, induces arterial thrombosis in a mouse model, and can be used to study HIV infection.

RM-133 is a promising pro-apoptotic agent which shows activity on various cancer cell lines.

UCM-13369 (Compound 4b) serves as an NPM1 inhibitor, effectively downregulating the pathway linked to mutant NPM1 C+ by specifically targeting the C-terminal DNA-binding domain of NPM1 C+. It induces apoptosis in AML cell lines and primary cells, making it a valuable tool for AML research [1].