lolcde in 2

LolCDE-IN-2 is a potent and selective inhibitor of the Lol protein (LolCDE) with antibacterial activity. LolCDE-IN-2 exerts its antibacterial activity by blocking the lipoprotein transport system in Gram-negative bacteria. LolCDE-IN-2 has an MIC of 2 μg/ml against Escherichia coli MG1655 and also shows inhibitory activity against Pseudomonas aeruginosa.

G0507 (5-(4-methoxyphenyl)-6-(5-methyl-2-thienyl)-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione) is a pyrrolopyrimidinedione compound that effectively inhibits the LolCDE ABC transporter. It suppresses the growth of Escherichia coli and induces the extracytoplasmic σE stress response. G0507 is commonly used as a chemical probe to study lipoprotein transport in Gram-negative bacteria.