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By Target- Apoptosis
- CDK(1)
- Pim(1)
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Results for "
lgh-447
" in TargetMol Product Catalog- Inhibitors & Agonists3
PIM-447 dihydrochloride
LGH447 dihydrochloride
T124731820565-69-2
PIM-447 dihydrochloride is an orally available and selective inhibitor of pan-PIM kinase(Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively).
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(1S,3R,5R)-PIM447 dihydrochloride
(1S,3R,5R)-LGH447 dihydrochloride
T13425
(1S,3R,5R)-PIM447 (dihydrochloride) is an inhibitor of PIM with IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2, and 0.369 μM for Pim3.
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PIM447
PIM 447, LGH447, LGH 447
T124751210608-43-7
PIM447 (LGH447) is an oral, selective pan-PIM kinase inhibitor with antitumor and bone-protective effects. It inhibits PIM1, PIM2, and PIM3, induces apoptosis, and decreases the viability, proliferation, and motility of HuH6 and COA67 cells. PIM447 suppresses tumorigenesis in hepatocellular carcinoma and can be used in the study of multiple myeloma.
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