leukopenia

Mephenytoin (Phenantoin) is an anticonvulsant and a substrate of CYP2C19 and CYP2B6.

LY223982 is an effective and selective LTB4 (leukotriene B4 receptor) antagonist that inhibits LTB4-induced neutrophil activation and transient leukopenia.

Losoxantrone (CI 941) is a DNA-binding agent with broad-spectrum antitumor activity. It can induce dose-dependent leukopenia.

Aselizumab (HuDreg-55) is a humanized IgG4 monoclonal antibody that targets L-selectin (CD62L), a cell adhesion molecule found on circulating neutrophils. L-selectin plays a crucial role in directing cell migration through chemotaxis to injury sites. Aselizumab has been associated with an increased incidence of infections and leukopenia, particularly following trauma, suggesting potential safety concerns that need further investigation in clinical contexts.

Polysaccharidase (Tremella polysaccharide), a fungal polysaccharide, exhibits immunoenhancing properties and holds potential for research in mitigating chemotherapy and radiotherapy-induced leukopenia [1] [2].