leukemogenesis

FB23 directly binds to FTO and selectively inhibits FTO's m6A demethylase activity. (FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis.)

ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor (IC50 = 0.62 μM) that alters m6A levels on mRNA, promotes differentiation and induces apoptosis, with antitumor activity.ALKBH5 is an N6-methyladenosine (m6A) demethylase that is closely related to leukemogenesis.

MI-3454 is an orally active, selective and potent inhibitor of Menin-MLL1 interaction that inhibits the proliferation and induces differentiation of acute leukemia cells with MLL1 translocation or NPM1 mutation.MI-3454 induces complete remission or regression of leukemia in a mouse model of leukemia with MLL1 rearrangement or NPM1 mutation through the down-regulation of key genes involved in leukemogenesis. complete remission or remission.