lamivudine

Lamivudine (BCH-189) is a reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease.

Lamivudine 13C,15N2, an impurity of Lamivudine (BCH-189), functions as an inhibitor of both HIV-1/2 reverse transcriptase and hepatitis B virus reverse transcriptase, classifying it as a nucleoside reverse transcriptase inhibitor (NRTIs).

Lamivudine sulfoxide, (R)- is a metabolite of Lamivudine. Lamivudine is a potent nucleoside reverse transcriptase inhibitor and antiviral agent used for the treatment of chronic hepatitis B.

Lamivudine, (+/-)-trans- is a reverse transcriptase inhibitor and zalcitabine analog. It is used for the treatment of hepatitis B (HBV) and Human Immunodeficiency Virus Type 1 (HIV-1).

Lamivudine (BCH-189) salicylate is an orally active nucleoside reverse transcriptase inhibitor (NRTI) that inhibits the reverse transcriptase activity of both HIV-1/2 and hepatitis B virus, while also demonstrating the ability to penetrate the central nervous system [1] [2].

Lamivudine triphosphate (3TCTP), a phosphorylated form of the nucleoside analogue Lamivudine, inhibits the reverse transcriptase of HIV or HBV, blocking viral replication through chain termination. It also acts as an inhibitor of the RdRp activity of the HCVNS5B subunit. Additionally, Lamivudine triphosphate can be incorporated into nascent RNA by SARS-CoV-2 RdRp, thereby preventing mutations in the newly synthesized SARS-CoV-2 RNA.

Lamivudinetriphosphate (3TCTP) TEA is a phosphorylated form of Lamivudine, a nucleoside analogue. It inhibits the reverse transcriptase of the HIV or HBV virus, preventing viral replication through chain termination. Additionally, Lamivudine triphosphate TEA is an inhibitor of RdRp activity in the HCV NS5B subunit. It can also be incorporated into nascent RNA by SARS-CoV-2 RdRp, thereby halting mutations in new SARS-CoV-2 RNA.

Lamivudine impurity 6 (lamivudine sulfoxide) is an impurity of Lamivudine.

Lamivudine impurity 5 is an impurity of Lamivudine.

Lamivudine impurity A RS is a bioactive chemical.

Lamivudine-13C-D2 the 13C and deuterated compound of Lamivudine. Lamivudine has a CAS number of 134678-17-4. Lamivudine is a reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease.

Lamivudine (Standard) is a reference standard for research and analysis in studies involving Lamivudine. Lamivudine (BCH-189) is a reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease.

Lamivudine-[13C,D2,15N2] (Standard) is a reference standard of Lamivudine-[13C,D2,15N2] intended for quantitative analysis, quality control, and related biochemical research applications.

Lamivudine impurity 8 is an impurity of Lamivudine.

Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase α, β and γ with Ki values of 300 μM, 12 μM and 112.25 μM, respectively. Apricitabine has shown good antiretroviral therapeutic efficacy in antiretroviral HIV-infected patients, with good tolerability and low selective resistance.

Besifovir Dipivoxil (LB80380) maleate is an oral prodrug of LB80317. Besifovir Dipivoxil maleate is effective in hepatitis B virus (HBV) DNA suppression for both treatment-naive and lamivudine-resistant chronic hepatitis B (CHB) patients.

3-Et-3TC (Page 87, Compound 3b) is a structural derivative of Lamivudine. This compound can inhibit the activation of the NLRP3 inflammasome and is useful for studying retinal degenerative diseases.

Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine. Lamivudine (2', 3'-dideoxy-3'-thiacytidine, commonly called 3TC) is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).

Alamifovir is an antiviral drug specific for HBV. It is a purine nucleotide analog prodrug that is active against wild-type and lamivudine-resistant HBV and acts by inhibiting viral DNA initiation and viral DNA packaging, thereby reducing HBV replication.

Bicyclol (SY801)(SY 801) is an anti-hepatitis drug. Oral administration of bicyclol normalizes the elevated serum transaminases (ALT, AST) by 50% in chronic viral hepatitis B and C, and also has a certain level of inhibiting HBV and HCV replication. In combination therapy of bicyclol with interferon alpha, lamivudine and adefovir dipivoxil in HBV or HCV, bicyclol may reduce YMDD mutant and side effects and increase the anti-viral efficacy.

TLR8 agonist 4 was effective in inhibiting both wild-type and drug-resistant (lamivudine and entecavir) HBV strains with their IC50 values of 0.15 and 0.10 μM, respectively.