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(1)
By Target- Histone Demethylase
- Mitochondrial Metabolism(1)
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Results for "
l2hydroxyglutaric acid disodium
" in TargetMol Product Catalog- Inhibitors & Agonists1
L-2-Hydroxyglutaric acid disodium
(S)-2-Hydroxyglutaric acid disodium
T1374863512-50-5
L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity(Km and Ki of 2.52 mM and 11.13 mM, respectively).
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(S)-2-Hydroxyglutaric acid
T1374913095-48-2
L-2-Hydroxyglutaric acid (L-2-HG) is a compartmentalized metabolite and a substrate for L-2-hydroxyglutarate dehydrogenase (L2HGDH). It inhibits histone demethylases and increases the expression of ATF4 and its target genes by activating the mTOR pathway. L-2-Hydroxyglutaric acid mediates the mTOR-ATF4 signaling pathway and can be used in biosensor research.
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