l-type cav1.2

Nisoldipine (BAY-k 5552) is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent.

AT1R antagonist 3 (Compound 1) is an antagonist of the angiotensin II type 1 receptor (AT1R) and an inhibitor of the L-type calcium channel CaV1.2 (IC50=0.57 μM). It exhibits vasodilatory effects in isolated rat aorta (10 μM, 88.7%) and shows antihypertensive activity in rat models.

Felodipine 3,5-Dimethyl Ester is an aromatic dihydropyridine compound that serves as a modulator of mineralocorticoid receptors and an inhibitor of voltage-dependent L-type calcium channels [CaV1.2].

HM12 is a covalent inhibitor of L-/T-type calcium channels. This compound effectively suppresses Cav1.2 (L-type) and Cav3.2 (T-type) calcium channels, while showing selectivity for N-type channels. The inhibitory effect produced by HM12 is irreversible and persists even after elution. HM12 is applicable in research related to hypertension, pain, epilepsy, and other conditions.