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(2)
By Target- Histone Demethylase
- Mitochondrial Metabolism(2)
- Endogenous Metabolite(1)
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Results for "
l-2-hydroxyglutaric acid
" in TargetMol Product Catalog- Inhibitors & Agonists2
- Natural Products1
L-2-Hydroxyglutaric acid
(S)-2-Hydroxyglutaric acid
T1374913095-48-2
L-2-Hydroxyglutaric acid (L-2-HG) is a compartmentalized metabolite and a substrate for L-2-hydroxyglutarate dehydrogenase (L2HGDH). It inhibits histone demethylases and increases the expression of ATF4 and its target genes by activating the mTOR pathway. L-2-Hydroxyglutaric acid mediates the mTOR-ATF4 signaling pathway and can be used in biosensor research.
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