k 811

K811 is an ASK1-specific inhibitor that prolongs survival in a mouse model of amyotrophic lateral sclerosis. K811 efficiently prevented cell proliferation in cell lines with high ASK1 expression and in HER2-overexpressing GC cells. Treatment with K811 reduced sizes of xenograft tumors by downregulating proliferation markers.

Pyridoxatin is a fungal metabolite that inhibits production of thiobarbituric acid reactive substance (TBARS). Pyridoxatin inhibits hemolysis induced by the free radical generator AAPH and is active against C. albicans.

BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with a Ki of 1 nM for human CCR1, exhibiting 250-fold selectivity over CCR2, CCR5, and CXCR4.

Cycloprothrin (GH414; NK-8116) is an insecticidal pesticide composed of two stereoisomers: (1R, alphaR)-Cycloprothrin and (R)-Cycloprothrin. The (1R, alphaR)-Cycloprothrin is approximately 6 times more effective against Mythimna separata larvae and 4 times more effective against Aphis medicaginis larvae than the (R)-Cycloprothrin.

BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.

AP 811, a selective antagonist of the atrial natriuretic peptide clearance receptor (APN-CR, NPR3) with a K i value of 0.48 nM, exhibits remarkable selectivity for NPR3 over NPR1 by more than 20,000-fold. Moreover, AP 811 effectively eliminates ANP-induced pump stimulation.