ipag

IPAG is a potent σ-receptor antagonist (pKi=4.3). IPAG can induce cell apoptosis.

Selexipag (ACT-293987)(NS-304) is prostacyclin receptor agonist that causes vasodilation in pulmonary vasculature and is used in the therapy of pulmonary arterial hypertension (PAH).

Sipagladenant (Compound I) is an orally active inverse agonist of the adenosine receptor A2A [1], with potential applications in research on frontal lobe dysfunction [2].

Lenipagrusin alfa is a natural homologous tetramer variant of Sophora japonica seed lectin (1-258), in its glycosylated form as alfa. Lenipagrusin alfa exhibits antitumor properties.

Albipagrastim alfa is a humanized antibody targeting CSF3R.

Selexipag Active Metabolite-D7 is a deuterated compound of Selexipag Active Metabolite. Selexipag Active Metabolite (T3S2007) has a CAS number of 475085-57-5. MRE-269 is an orally available and long-acting prostacyclin receptor agonist prodrug. MRE-269 is used for the treatment of pulmonary arterial hypertension. MRE-269 is an active metabolite of Selexipag (S253150).

Selexipag-D7 is a deuterated compound of Selexipag. Selexipag (T3216) has a CAS number of 475086-01-2. Selexipag (NS-304) is prostacyclin receptor agonist that causes vasodilation in pulmonary vasculature and is used in the therapy of pulmonary arterial hypertension (PAH).

The physiologic effect of Methyl Paraben (Nipagin) is by means of Increased Histamine Release, and Cell-mediated Immunity. Methyl Paraben (Nipagin) is an antimicrobial agent, preservative, flavouring agent. Methyl Paraben (Nipagin) is a constituent of cloudberry, yellow passion fruit, white wine, botrytised wine and Bourbon vanilla.The physiologic effect of Methyl Paraben (Nipagin) has been shown to exhibit anti-microbial function.

Ethyl gallate (gallic acid ethyl ester) obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependent manner. Ethyl gallate can inhibit the abilities of invasion of breast cancer in vitro by inhibiting the mRNA levels of MMP-9/MMP-2, phosphorylation of Akt and protein expression of NF-κB and inhibits hydrogen peroxide signaling, may represent an alternative class of vasopressors for use in septic shock. Also, Ethyl gallate suppresses proliferation and invasion in human breast cancer cells by modulating the PI3K/Akt pathway, which may contribute to inhibiting their downstream targets such as NF-κB p-65, Bcl-2/Bax, and mRNA levels of MMP-2 and MMP-9 in breast cancer cells, could be used as potential antioxidants with safe therapeutic application in cancer chemotherapy.

Dodecyl gallate is an antioxidant commonly used in food manufacturing and in the pharmaceutical and cosmetic industries. It is also active against animal viruses such as African swine fever virus (ASFV).

Saroglitazar (Lipaglyn) is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ.