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int 777 r enantiomer

" in TargetMol Product Catalog.
  • Inhibitors & Agonists
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    TargetMol | All_Pathways
INT-777 R-enantiomer
S-EMCA R enantiomer
T116621198786-98-9
INT-777 is the R-enantiomer of INT-777, less potent than INT-777,EC50 of 4.79 μM for TGR5.
  • $1,820
8-10 weeks
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QTY
INT-777
S-EMCA
T11662L1199796-29-6In house
INT-777 (S-EMCA) is a potent, selective TGR5 agonist with an EC₅₀ of 0.82 μM. Following subarachnoid hemorrhage in rats, INT-777 inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway. INT-777 exhibits multiple effects, including metabolic regulation, anti-inflammatory activity, cholagogue effects, and vascular protection. INT-777 can be used in research on diseases such as metabolic syndrome, non-alcoholic fatty liver disease, inflammatory bowel disease, and pulmonary arterial hypertension.
  • $139
In Stock
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