indolinone

MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.

Compound PDK0232, with CAS No. 480-91-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0232 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

SU11652 is an effective and competitive receptor tyrosine kinase (RTK) inhibitor, including VEGFR, FGFR, PDGFR, and Kit. SU11652 disrupts the function of all forms of mutant Kit and may be used in the study of cancers involving Kit mutations.

Oxindole (Indolin-2-one) is an aromatic heterocyclic building block, and its 2-indolinone derivatives are lead compounds in kinase inhibitor research. The oxindole structure is utilized in receptor tyrosine kinase (RTK) inhibitors, such as SU4984 and intedanib, making the RTK family a significant therapeutic target for anti-cancer drug development.

Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFRβ (IC50: 80/2 nM), and c-kit.

SU5208 (3-[(Thien-2-yl)methylene]-2-indolinone) is a compound with bioactivity.SU5208 inhibits vascular endothelial growth factor receptor-2 (VEGFR2).

hCA/VEGFR-2-IN-5 (compound 9) is an indolinone phenylsulfonamide and a potential dual inhibitor of hCA IX/XII and VEGFR-2, which are associated with cancer. The compound has IC50 values of 0.38 μM for VEGFR-2, 40 nM for hCA IX, and 3.2 nM for hCA XII. It exhibits antitumor activity.