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Results for "
human ox2r
" in TargetMol Product Catalog- Inhibitors & Agonists4
- Peptide Products1
jnj-54717793
T96541628843-99-1In house
JNJ-54717793 is an orally active, brain-penetrating compound that acts as a selective and high-affinity antagonist of the orexin-1 receptor (OX1R) with a plasma EC50 of 85 ng mL. It demonstrates K_i values of 16 nM for hOX1R (human OX1R) and 700 nM for hOX2R, indicating its strong preference for hOX1R over hOX2R. JNJ-54717793 is recognized for its effectiveness in the treatment of anxiety disorders.
Inquiry
Orexin A (human, rat, mouse) acetate
Hypocretin-1 (human, rat, mouse) acetate
T73658
Orexin A (human, rat, mouse) acetate (Hypocretin-1) is an excitatory neuropeptide with analgesic properties. It activates Orexin-1 (OX1R) and Orexin-2 (OX2R) receptors, used for studying neurodegenerative diseases.
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QTY
Seltorexant
JNJ-42847922
T12877L1293281-49-8
Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human and rat OX2R).
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Seltorexant hydrochloride
JNJ-42847922 hydrochloride
T128771293284-49-7
Seltorexant hydrochloride is a selective, orally active and high-affinity antagonist of OX2R with pKi values of 8.0 and 8.1 for human and rat OX2R.
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