human ox2r

Seltorexant hydrochloride is a selective, orally active and high-affinity antagonist of OX2R with pKi values of 8.0 and 8.1 for human and rat OX2R.

Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human and rat OX2R).

Orexin A (human, rat, mouse) acetate (Hypocretin-1) is an excitatory neuropeptide with analgesic properties. It activates Orexin-1 (OX1R) and Orexin-2 (OX2R) receptors, used for studying neurodegenerative diseases.

Anti-OX2R/CD200R1 Antibody is a human-derived antibody expressed in CHO cells and targets OX2R/CD200R1. The predicted molecular weight (MW) of Anti-OX2R/CD200R1 Antibody is 146.58 kDa. For the isotype control of Anti-OX2R/CD200R1 Antibody, refer to Human IgG4 kappa, Isotype Control.

Anti-CD200R1/OX2R Antibody (I-4P) is a human monoclonal antibody (mAb) targeting CD200R1/OX2R. It is utilized in the study of solid tumors. Recommended isotype control: Human IgG4 kappa, Isotype Control.

Orexin A-13C18,15N3 (human, rat, mouse) ((Hypocretin-1-13C18,15N3 (human, rat, mouse)) TFA) is a compound labeled with 13C and 15N, and it is a form of Orexin A (human, rat, mouse). Orexin A, also known as Hypocretin-1, is a 33 amino acid excitatory neuropeptide involved in various central and peripheral processes. It binds to and activates two G protein-coupled receptors: the Orexin-1 receptor (OX1R) and Orexin-2 receptor (OX2R), playing a crucial role in regulating feeding behavior. Orexin A is also an active molecule with potent antinociceptive and anti-hyperalgesic properties.

Orexin A-13C6,15N (human, rat, mouse) (also known as Hypocretin-1-13C6,15N (human, rat, mouse)) TFA is an isotopically labeled version of Orexin A (human, rat, mouse). This 33-amino acid excitatory neuropeptide is involved in various central and peripheral processes. It binds to and activates two G protein-coupled receptors, the Orexin-1 receptor (OX1R) and the Orexin-2 receptor (OX2R), playing a crucial role in regulating feeding behavior. Additionally, Orexin A (human, rat, mouse) is an effective agent against nociception and hyperalgesia.