hpxr

Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist

Specific PXR antagonist 70 is a selective pregnane X receptor (PXR) antagonist with an IC50 of 540 nM and Ki of 390 nM for human PCR and enhances the chemosensitivity of cancer cells.

DL5050 is a selective agonist for the human constitutive androstane receptor (hCAR). This compound demonstrates superior affinity and selectivity for hCAR by inducing expression of CYP2B6 (the target of hCAR) at the mRNA and protein levels, rather than CYP3A4 (the target of the human pregnane X receptor, hPXR). As a selective hCAR agonist, DL5050 not only serves as a crucial tool molecule for studying hCAR's biological function but also holds potential as a lead compound for the development of therapeutic applications targeting hCAR.

4,8-Dioxa-3H-perfluorononanoic acid, a type of per- and polyfluoroalkyl substance (PFAS), exhibits affinity for the human pregnane X receptor (hPXR) and demonstrates potential agonistic activity.

Pyributicarb (TSH-888) is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).

JMV6944 is a PXR agonist that competitively inhibits the binding of ligands to the ligand-binding domain (LBD) of human PXR, with an IC50 value of 680 nM. Additionally, JMV6944 induces the expression of CYP3A4 mRNA in cultures of freshly isolated primary human hepatocytes.

Pyributicarb (Standard) is the standard substance of Pyributicarb, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Pyributicarb (TSH-888) is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).

Ganolucidic acids B demonstrated the ability to induce hPXR-mediated CYP3A4 expression.